The adverse effects connected to meperidine are qualitatively much like those produced by morphine. Meperidine is associated with a reduced incidence of constipation and urinary retention. Tolerance develops to the steps of meperidine, and also the drug contains a superior addictive potential.
The concomitant usage of cimetidine may perhaps decrease the clearance and quantity of distribution of meperidine also the formation on the metabolite, normeperidine, in healthier topics
Opioids are sought by drug abusers and individuals with addiction Ailments and so are matter to criminal diversion. Look at these risks when prescribing or dispensing Demerol Injection. Techniques to cut back these risks incorporate prescribing the drug in the smallest ideal amount.
WARNING: Constraints of use DBL Pethidine Hydrochloride Injection must only be employed when your doctor decides that other procedure possibilities are not able to effectively regulate your suffering or You can not tolerate them.
Meperidine is significantly less powerful via the oral than with the parenteral route, but the precise ratio of oral to parenteral success is unknown.
In case you are in excess of 65 many years of age maybe you have an increased chance of having Negative effects. See the information below and, if you should, inquire your physician or pharmacist Should you have any additional questions about side effects.
It is vital you get rid of unwelcome opioid medicines safely — unused medicines can be returned to any pharmacy. You should not continue to keep unused pethidine 'just just in case' because this may lead to inappropriate use.
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The dose of Demerol Injection must be proportionately reduced (generally by twenty five to fifty p.c) when administered concomitantly with phenothiazines and a number of pethidine 100mg/2ml other tranquilizers since they potentiate the motion of Demerol Injection.
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If unacceptable opioid-associated adverse reactions are noticed, look at cutting down the dosage. Change the dosage to acquire an suitable balance amongst management of pain and opioid-related adverse reactions.
Meperidine really should not be administered intravenously Unless of course a narcotic antagonist and the amenities for assisted or managed respiration are straight away available. When meperidine is specified parenterally, Specially intravenously, the affected individual really should be lying down.
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Advise each individuals and caregivers with regard to the risks of respiratory depression and sedation when Demerol Injection is utilised with benzodiazepines or other CNS depressants (like Liquor and illicit drugs). Recommend people not to drive or operate weighty equipment till the effects of concomitant use of the benzodiazepine or other CNS depressant are already identified.